Tutino GE, Tam CHT, Ozaki R, et al. - Since women with gestational diabetes mellitus are at increased risk for T2D, researchers conducted this prospective nested case-cohort study to describe the connection between maternal glycemia during pregnancy with long-term outcomes. Study participants were recalled for follow-up with a thorough assessment including oral glucose tolerance test at 8, 15 and 22 years. Participants in the study were 121 women with a mean follow-up period of 22.5 years, and a mean age of 50.3 years. At 22-year follow-up, Chinese women with a history of gestational diabetes have a high prevalence of impaired glucose tolerance/T2D. Glucose levels are strongly associated with those of middle age during mid-pregnancy. Both fasting and 2-h glucose during pregnancy were strongly linked to glycemic indices at follow up. Gestational diabetes was related to impaired β-cell function, which after index pregnancy remained relatively stable.