Raugi DN, Ba S, Cisse O, et al. - Researchers sought to gather data on programmatic treatment outcome for people living with HIV-2 in West Africa, where the virus is most prevalent. For participation in this prospective, longitudinal observational cohort study, they invited HIV-2-infected adults who had initiated or were receiving ART through the Senegalese national AIDS program. At two sites, 291 participants were enrolled for 926.0 person-years of follow-up over 13 years. Among these patients, 21 deaths were reported (7.2%), and 117 individuals (40.2%) were lost to follow-up, including 43 (14.7%) who had an initial visit but never returned for follow-up. Participants in the Senegalese national AIDS program had earlier ART initiation in the course of disease, and improved outcomes were reported in correlation to receiving more modern therapeutic regimens. Despite these achievements, there remained sub-optimal HIV-2 treatment, and significant challenges to improving care.