Rebolj M, et al. - Data from Singaporean women who underwent single mammography screened at age 50–64 years was assessed by the researchers to demonstrate how long a single density measurement could be taken in (post-)menopausal women that remained informative. The excess risk of breast cancer, calculated as an odds ratio (OR) with conditional logistic regression and adjusted for body mass index was measured was correlated with 26–50% and with 51–100% density in comparison with ≤25% density by time since the screening. A total of 490 women had breast cancer, out of which 361 were diagnosed because of symptoms following the screening. An excess risk of breast cancer in women with 51–100% breast density was noted that did not appear to attenuate with time. For women with 26–50% breast density, the excess risk with a stable OR of about 2 was also seen. When the analyses were restricted to post-menopausal women, non-users of hormonal replacement therapy and following stratification by age at density measurement, these patterns were strong. Hence, during at least the subsequent 10 years, a single breast density measurement recognized women with an excess risk of breast cancer.