Tang X, et al. - A sum of 85 candidates were studied to estimate the long-term effectiveness and safety of repeated sodium hyaluronate injections for the treatment of knee pain due to Kashin-Beck disease (KBD). A reduction in visual analog scale (VAS) from 65.06 ± 12.21 mm at baseline to 30.17 ± 11.92 mm at 6 months was reported with maintenance for 24 months (35.79 ± 7.92 mm). They observed improvement in knee KBD symptoms with repeated once yearly cycles of intra-articular sodium hyaluronate injections.