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Long-term effects of repeated botulinum neurotoxin A, bimanual training, and splinting in young children with cerebral palsy

Developmental Medicine & Child Neurology Aug 09, 2019

Lidman GRM, et al. - In this longitudinal study, researchers examined long-term development of hand function after repeated botulinum neurotoxin A (BoNT-A) and occupational therapy at a young age. The study sample consisted of 20 children with unilateral spastic cerebral palsy (14 males, six females; median inclusion age 3y 1mo, range 1y 11mo–4y 3mo). After a randomized controlled trial, 10 children received occupational therapy and 10 repeated BoNT-A plus occupational therapy during 1-year. The authors discovered that the improvement in Assisting Hand Assessment [AHA] (7.5 AHA units) was retained at the final follow-up after BoNT-A plus occupational therapy. No association was found between active supination and AHA. According to findings, the bimanual performance was maintained after BoNT-A plus occupational therapy, while it increased through follow-up in the occupational therapy group, suggesting that combined intervention earlier gave access to bimanual skills.
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