Gallo FG, Plaitano C, Esposito Veneruso P, et al. - Researchers conducted this retrospective analysis to examine the motor outcome of early Botulinum toxin (BT) treatment in patients affected by large-angle infantile esotropia (IE). Between 2004 and 2019, 130 medical charts of IE patients who had BT injections were analyzed. Within 13 months of age, all patients underwent BT injections. Thirty patients, matching the criteria for inclusion, were involved in the study. The result after 1 Botulinum toxin injection presented a very low success rate (6.7%) at last follow-up (28.3 ± 7.2 months). The data indicate that one Botulinum toxin injection in children affected by large-angle infantile esotropia makes it possible to substantially minimise the deviation, but does not avoid the need for surgical care.