Adachi K, et al. - In this investigation involving 8,123 people (mean age 54.2 ± 9.3 years), researchers illuminated the long-term impact of Helicobacter pylori eradication on the prevalence of reflux esophagitis (RE). Participants in the study were patients who visited the medical center for an annual checkup between April 2016 and December 2018 and in whom the status of H. pylori infection could be determined. In 898 subjects, RE was noted. Prevalence rates in subjects without and with H. pylori infection and with a post-eradication status were 14.0%, 3.7%, and 10.1%, respectively. Multiple logistic regression analysis of those positive for RE showed significant risk factors in the male gender, elevated body mass index, habitual drinking, habitual smoking, larger diaphragmatic hiatus size, and milder gastric mucosal atrophy. Multiple logistic regression analysis showed a longer duration after H. pylori eradication to be a significant risk factor for RE. The risk of developing RE in people following eradication of H. pylori was considered to be lower as compared with those never infected. However, as the period following H. pylori eradication is extended, the risk for RE rises.