Imai H, Tetsumoto A, Yamada H, et al. - Researchers conducted the study for analyzing the long-term impact of cystotomy with or without fibrinogen clot removal for refractory cystoid macular edema secondary to diabetic retinopathy. Retrospective analyses of the medical records of 30 patients (30 eyes) with refractory cystoid macular edema secondary to diabetic retinopathy who had followed up for 12 months after the surgery were conducted. Cystoid macular edema relapsed in seven of 30 eyes during the follow-up period. For refractory cystoid macular edema secondary to diabetic retinopathy, the cystotomy with or without fibrinogen clot removal can be a promising treatment choice.