Oh YS, et al. - In 340 consecutive patients presenting with one or more clinical or angiographic features who would have precluded inclusion in randomized trials, researchers explored the long-term consequences of contemporary drug-eluting stent (DES)-based revascularization for left main coronary artery disease in this retrospective study. Based on prespecified inclusion and exclusion criteria used in clinical trials, two groups of patients were defined: the exclusion group (group E; n=120) and the inclusion group (group I; n=220). There was no association of group E with a higher incidence of major adverse cardiac or cerebrovascular events, in the propensity score-matched population. One or more high-risk features or comorbidities representative of exclusion criteria of earlier randomized trials were present in nearly a third of patients who had percutaneous coronary intervention (PCI) for unprotected left main coronary artery stenosis, in this real-world registry. In these patients, the feasibility of PCI using DES was evident.