Gohel MS, Mora J, Szigeti M, et al. - Researchers sought to evaluate the clinical and cost-effectiveness of early endovenous ablation of superficial venous reflux in patients with venous leg ulceration.  They performed a multicenter, randomized clinical trial including 450-patient with venous leg ulceration of less than 6 months’ duration and superficial venous reflux. Participants underwent randomization to receive either compression therapy with early endovenous ablation within 2 weeks of randomization (early intervention, n = 224) or compression with deferred endovenous treatment of superficial venous reflux (deferred intervention, n = 226). Accelerated venous ulcer healing was observed in correlation with undergoing early endovenous ablation with compression. Further, it was associated with reduced overall incidence of ulcer recurrence, and was highly cost-effective compared with compression with deferred intervention. In view of findings, they emphasize revising leg ulcer care pathways to include early assessment and treatment of superficial venous reflux to attain clinical and cost benefits.