Gohel MS, Mora J, Szigeti M, et al. - Researchers examined the clinical and cost-effectiveness of early endovenous ablation of reflux in patients with venous leg ulceration and superficial reflux. The EVRA randomized clinical trial was performed including 450 participants (450 legs) with venous leg ulceration of less than 6 months’ duration and superficial venous reflux. Random allocation of the patients to receive compression therapy with early endovenous ablation within 2 weeks of randomization (early intervention, n = 224) or compression with deferred endovenous treatment of superficial venous reflux (deferred intervention, n = 226) was performed. Outcomes revealed accelerated venous ulcer healing, decreased overall incidence of ulcer recurrence, and high cost-effectiveness in correlation with early endovenous ablation with compression vs compression with deferred intervention. Based on these findings, they emphasize including early assessment and treatment of superficial venous reflux in leg ulcer care pathways to deliver clinical and cost benefits.