Long-term cardiovascular morbidity and mortality in patients treated for differentiated thyroid cancer
Clinical Endocrinology Jan 20, 2019
Pajamäki N, et al. - In this retrospective cohort study, researchers assessed long-term cardiovascular morbidity and mortality in patients treated for differentiated thyroid cancer (DTC) and evaluated the impact of TSH suppression and radioiodine (RAI) treatment on the cardiovascular outcome. Between 1981 and 2002, patients treated for DTC at 2 Finnish University hospitals (n = 901) were compared with a randomly chosen reference group (n = 4,485) matched for age, gender and the place of residence. According to findings, morbidity was more common in patients with DTC due to any cardiovascular diseases (CVD) and due to all arrhythmias and atrial fibrillation (AF). Investigators found that the increased cardiovascular morbidity was confined to patients with a mean TSH level below 0.1 mU/L and to those treated with RAI. However, cardiovascular mortality in patients was lower than controls because of lower coronary artery disease mortality.
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