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Long-term air pollution exposure under EU limits and adolescents’ lung function: Modifying effect of abnormal weight in GINIplus/LISA birth cohorts

Chest Feb 17, 2021

Zhao Q, Kress S, Markevych I, et al. - Researchers conducted this observational analysis to determine the impact of weight status on the influences of long-term air pollution on adolescents’ pulmonary function, especially in regions with pollution levels much lower compared with the current European Union air quality standards. From the German GINIplus (The German Infant study on the influence of Nutrition Intervention plus environmental and genetic influences on allergy development ) /LISA (The Influence of Life style factors on the development of the Immune System and Allergies in East and West Germany) birth cohorts, a total of 2,224 adolescents were inquired. At age 15 years, evaluation of lung function was done. Experts used percentiles of body mass index to define under, normal and over/obese weights. Findings revealed an association between exposure to low-to-moderate levels of air pollution and lung function impairment for adolescents with abnormal weights. An aggravation of the adverse impact was evident in relation to longer exposure. Further inquiry is warranted to determine if there may be a critical exposure window since birth.

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