Park S, Ahn JM, Lee K, et al. - Given that acuity of clinical presentation may impact decision-making of percutaneous coronary intervention (PCI) and coronary-artery bypass grafting (CABG) for left main coronary artery (LMCA) disease, researchers ascertained if the clinical indication for myocardial revascularization may influence the relative long-term impact following PCI and CABG. Interaction between acuity of clinical presentation (acute coronary syndromes [ACS] or non-ACS) and revascularization strategy on 10-year outcomes was examined in the MAIN-COMPARE study involving 2,240 patients with LMCA disease treated with PCI (n = 1,102) or CABG (n = 1,138). Overall, 1,603 patients with ACS and 637 patients with non-ACS were presented. No significant interaction was identified between the acuity of clinical indication and the relative treatment impact of PCI compared with CABG on 10-year clinical outcomes in patients with LMCA disease.