Zheng ZQ, et al. - Researchers focused on the clinical importance of long non-coding RNAs (lncRNAs) and their regulatory mechanisms in nasopharyngeal carcinogenesis (NPC). They identified 384 dysregulated lncRNAs, based on microarray analysis. FAM225A was identified as one of the most up-regulated lncRNAs in NPC. In NPC, a significant link between FAM225A and poor survival was identified. NPC cell proliferation, migration, invasion, tumor growth and metastasis were promoted by FAM225A. For sponging miR-590-3p and miR-1275, FAM225A acted as a competing endogenous RNA (ceRNA), on a mechanistic level, that resulted in the upregulation of their target integrin β3, and the activation of FAK/PI3K/Akt signaling to promote NPC cell proliferation and invasion. In this study, a potential ceRNA regulatory pathway was proposed by which FAM225A was shown to promote tumorigenesis and metastasis in NPC.