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Long‐term follow‐up of diabetic and non‐diabetic patients with chronic hepatitis c successfully treated with direct acting antiviral agents

Liver International Oct 07, 2020

Ciancio A, Ribaldone DG, Dotta A, et al. - A long‐term prospective study on diabetic and non‐diabetic patients with chronic hepatitis C cured by Direct Antiviral Agents (DAAs) was performed. In this study, 15.7% were diabetic (Group 1) and 84.3% non‐diabetic (Group 2); changes in fasting glucose (FG) and glycated haemoglobin (HbA1c) levels were assessed in Group 1 while the incidence of LRE was established in the whole cohort, among 893 recruited patients. Researchers assessed variations between groups and established independent predictors of unfavourable clinical outcome. The results of this study exhibited that SVR achieved by DAAs is correlated with long‐term improvement of glycometabolic control in diabetic patients but among cirrhotics, DM still exerts a detrimental impact on the liver.

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