Reinhorn D, Mutai R, Yerushalmi R, et al. - Researchers herein analyzed randomized control trials that compared locoregional therapy (LRT) and systemic therapy to standard therapy alone in de novo metastatic breast cancer. They calculated hazard ratios and their associated 95% confidence intervals as well as pooled them in a meta-analysis employing generic inverse variance. Analyses involved 4 trials consisting of 970 patients. LRT involved standard surgery to the primary breast tumor in all studies, and adjuvant radiation per standard of care was needed in 3 studies. Findings revealed absence of a connection between LRT and improved overall survival of de novo metastatic breast cancer. Consistent findings were observed among different breast cancer subgroups.