Location of glomerular immune deposits, not codeposition of immunoglobulin G, influences definitive renal outcomes in immunoglobulin A nephropathy
Nephrology Dialysis Transplantation Aug 19, 2017
Alvarado AS, et al. – Aim was to figure out if the location of glomerular immune deposits, not codeposition of immunoglobulin G, influenced definitive renal outcomes in immunoglobulin A nephropathy. In the peripheral capillary walls (PCWs), both IgG co–deposition and the location of glomerular immune deposits exhibited an association with greater histologic activity on renal biopsy. However, only the location of glomerular immune deposits in the PCWs was associated with a significantly increased risk for end–stage renal disease, transplant, death and/or doubling of serum creatinine (SCr).
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