Guo L, Xie G, Wang R, et al. - Because of the lack of exact therapeutic target, chemotherapy is still the relied systemic treatment of triple-negative breast cancer (TNBC). In terms of local treatment, based on the highly malignant characteristics of TNBC, uncertainty remains whether more aggressive local treatment should be administered to patients. Based on the SEER database, they assessed 13,262 TNBC patients undergoing chemotherapy. Division of patients was done according to local treatment methods into breast-conserving surgery with radiotherapy (BCS + RT), total mastectomy alone and total mastectomy with radiotherapy (Mastectomy+RT). Per outcomes, relatively higher or similar survival benefit of breast-conserving surgery with radiotherapy was recorded when compared with total mastectomy TNBC patients.