Akelma H, et al. - Among patients with fear of pain before port operation, because of multiple surgeries in the past, whether superficial cervical plexus block (SCPB) or local infiltration anesthesia offers better comfort was investigated in this study. Participants were 100 cancer-diagnosed patients who were classified into two categories: Group LM with 50 patients for whom the landmark technique with local infiltration anesthesia was used for intravenous entry; and Group US with 50 patients for whom ultrasonography (USG) was used for venous entry with SCPB as anesthesia. In Group LM and GroupUS, visual analog scale scores were 4.04 and 2.62, and surgeon satisfaction was 1.96 and 2.38, respectively. Findings revealed that better comfort for both patient and surgeon was achieved in relation to port catheter placement using USG and SCPB, supported by routine sedation, in the patient group with a high level of pain and anxiety.