Shi X, et al. - Objective of this study was to determine the clinical value and biological role of tumor suppressor candidate 7 (TUSC7) in cancers. Data portrayed that through regulation of ubiquitination, decreased TUSC7 was associated with cancer prognosis in cancer patients.

Methods

• In order to seek the correlation of TUSC7 expression levels and tumor size, lymph node metastasis, overall survival, and other clinical related indicators, a meta-analysis of 655 cancer patients from 9 selected articles, was conducted.
• Analysts extracted the pan-cancer survival data in the Cancer Genome Atlas (TCGA) and meta-analyzed to validate the results from the meta-analysis.
• They downloaded sixty thousand public Affymetrix microarrays data and used to mine signal pathways associated with TUSC7.

Results

• Between cancerous and paracancerous tissues, TUSC7 was differentially expressed.
• Shown by the pan-cancer survival data meta-analysis, TUSC7 had a protective effect in the prognosis of cancer.
• No correlation was observed between TUSC7 expression and age, gender, tumor size, tumor differentiation, lymph node metastasis or TNM staging in the reported cancers.
• As per pathway analysis, TUSC7 was co-expressed with genes enriched in ubiquitin-mediated proteolysis.