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LncRNA as a diagnostic and prognostic biomarker in bladder cancer: A systematic review and meta-analysis

OncoTargets and Therapy Oct 11, 2018

Quan J, et al. - Researchers examined the link between long non-coding RNA (lncRNA) expression and survival in bladder cancer, in order to find out novel diagnostic and prognostic biomarkers for bladder cancer. This is the first meta-analysis assessing this association. Databases were searched and using STATA 14.0 software, the data from collected studies was analyzed and the forest plots were constructed. For each meta-analysis, a different effect size was selected. Overall, 13 articles about clinicopathological characteristics, six articles about diagnosis, and 16 articles about prognosis were analyzed. Findings suggested that LncRNAs hold promise as novel diagnostic and prognostic markers in bladder cancer. UCA1 was expected to be a diagnostic biomarker for bladder cancer, while poor disease-free survival/recurrence-free survival/disease-specific survival was reported in association to the aberrant expression of HOTAIR and GAS5.
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