Corma-Gómez A, Macías J, Morano L, et al. - Patients with low risk of developing esophageal variceal bleeding (VB) episodes are identified using liver stiffness (LS)-based strategies in the setting of HCV active infection, safely avoiding unnecessary upper esophagogastroduodenoscopy (UGE) screening, so researchers assessed how well this strategy works after after sustained virological response (SVR) in HCV-infected patients with cirrhosis, with or without HIV-coinfection. Researchers conducted this multicenter prospective cohort study including 435 patients, 284 (65%) of whom were coinfected with HIV. A first episode of VB developed in seven (1.6%) patients following SVR. Findings support the accuracy of predictive LS-based strategies after SVR in identifying HCV-infected patients, HIV-coinfected or not, with low risk of developing VB during follow-up. In these specific patients, use of HIV cirrhosis criteria maximizes the number of spared UGEs while not missing any VB episode.