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Liver resection for nonalcoholic fatty liver disease-associated hepatocellular carcinoma

Journal of the American College of Surgeons Aug 10, 2019

Koh YX, Tan HJ, Liew YX, et al. - The worldwide incidence of non-alcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (HCC) is increasing, so researchers described the perioperative and long-term outcomes following liver resection. In addition, they examined the impact of the histological severity of non-alcoholic steatohepatitis and how perioperative outcomes and long-term survival are influenced by it. Among a total of 996 patients who had liver resection for HCC at their institution, 844 patients had non-NAFLD HCC while 152 patients had NAFLD HCC. They noted greater surgical morbidity and posthepatectomy liver failure in correlation with NAFLD associated HCC, but more favorable long-term survival outcomes vs non-NAFLD etiologies.

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