Live respiratory syncytial virus (RSV) vaccine candidate containing stabilized temperature-sensitivity mutations is highly attenuated in RSV-seronegative infants and children
The Journal of Infectious Diseases Mar 07, 2018
Buchholz UJ, et al. - Researchers administered an intranasal dose of 105.3 plaque-forming units (PFU) of RSV cold-passage/stabilized 2 (RSVcps2) vaccine candidate or placebo to RSV-seronegative 6–24-month-old children and assessed RSV serum neutralizing antibody titers before and 56 days after vaccination, vaccine virus infectivity, reactogenicity, and genetic stability. Findings suggested that in 6–24-month-old RSV-seronegative children, RSVcps2 was well tolerated and moderately immunogenic and had increased genetic stability.
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