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Liraglutide pharmacokinetics and exposure‐response in adolescents with obesity

Pediatric Obesity May 28, 2021

Petri KCC, Hale PM, Hesse D, et al. - This research sought to conduct a population pharmacokinetic and exposure-response analysis of liraglutide by meta-analysis of data from trials conducted in children, adolescents, and adults with obesity. Researchers assessed the effect of covariates on body weight, age group (children, adolescents, and adults), and gender on liraglutide exposure in adolescents compared with previous results in adults. They assessed the exposure-response relationship of liraglutide for the change from baseline in body mass index standard deviation score (BMI SDS) in adolescents and compared to that in adults. The results supported similar liraglutide exposures in adolescents and adults; body weight was the most important covariate affecting exposure. As per the data, an exposure-response association was established for liraglutide.

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