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Liposomal bupivacaine vs plain bupivacaine in periarticular injection for control of pain and early motion in total knee arthroplasty: A randomized prospective study

Journal of Arthroplasty Mar 21, 2018

Zlotnicki JP, et al. - This study was conducted to compare the effectiveness of periarticular injection using long-acting vs short-acting preparations, with a focus on pain relief, total narcotic usage, and completion of physical therapy goals, specifically range-of-motion. At early and late time points, minimal significant differences were noted between liposomal bupivacaine and plain bupivacaine. A superiority of both preparations of periarticular injection over control pain regimens was noted but in direct comparison, these preparations were equivalent to one another.
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