Chaudhary N, Choudhary BS, Shah SG, et al. - The present study was conducted to explore lipocalin 2 inhibits ferroptosis by reducing intracellular iron levels and stimulating the expression of glutathione peroxidase4 and a component of the cysteine glutamate antiporter, xCT. The outcomes demonstrate that lipocalin 2 is a significant therapeutic target and that the monoclonal antibody described in this study can serve as the basis for a potential therapeutic in patients that do not respond to chemotherapy.