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LIN28A, a sensitive immunohistochemical marker for Embryonal Tumor with Multilayered Rosettes (ETMR), is also positive in a subset of Atypical Teratoid/Rhabdoid Tumor (AT/RT)

Child's Nervous System Oct 20, 2017

Rao S, et al. - The topic of exploration herein was the immunoreactivity of LIN28A across all embryonal CNS tumors. The findings unveiled that LIN28A was a sensitive immunohistochemistry (IHC) marker for the diagnosis of Embryonal Tumor with Multilayered Rosettes (ETMR). LIN28A was not found to be specific to ETMRs and such immunoreactivity possibly appeared in a proportion of Atypical Teratoid/Rhabdoid Tumor (AT/RT), among CNS embryonal tumors.
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