LIMD1 is a survival prognostic marker of gastric cancer and hinders tumor progression by suppressing activation of YAP1
Cancer Management and Research Oct 17, 2018
Zhang D, et al. - Researchers investigated the prognostic and biological roles of LIMD1 in gastric cancer (GC). Using the online tool Kaplan–Meier Plotter, they assessed the prognostic ability of LIMD1 in GC patients. They used in vitro assays to examine the biological functions of LIMD1 in GC. LIMD1 was identified as a convincing prognostic marker as well as a potentially therapeutic target for GC due to the positive correlation of LIMD1 expression level with prognosis in GC patients irrespective of tumor stage, size, lymph node, metastasis, Lauren’s classification, differentiation, gender, treatment, and ERBB2 amplification status. Impeded tumor growth, cell motility, invasiveness, and metastasis were seen in relation to LIMD1 overexpression. In GC cells, knockdown of LIMD1 promoted these phenotypes.
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