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Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies

International Journal of Cancer Feb 11, 2021

Jayasekara H, MacInnis RJ, Barroso LL, et al. - The present study was conducted to examine the relationship between long‐term alcohol intake and the risk of stomach cancer and its subtypes. Researchers conducted a pooled analysis of data collected at baseline from 491,714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. They calculated hazard ratios (HR) and 95% confidence intervals (CI) for incident stomach cancer in relation to lifetime alcohol intake and group‐based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. The outcomes demonstrated that limiting alcohol use over a lifetime, especially avoiding heavy use during early adulthood, might help prevent non‐cardia stomach cancer. There were 1,225 incident stomach cancers (78% non‐cardia) diagnosed over 7,094,637 person‐years; 984 in 382,957 study participants with lifetime alcohol intake data (5,455,507 person‐years). A weak positive correlation with non‐cardia cancer was seen, but lifetime alcohol intake was not linked with overall stomach cancer risk. A weak inverse association with cardia cancer was also seen. As per the findings, heterogeneous associations observed for cardia and non‐cardia cancers may demonstrate etiologic differences.

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