Zhao Z, et al. - Researchers sought to determine the effectiveness of lifestyle interventions on Barrett esophagus (BE) risk. They explored PubMed, Embase, and Web of Science up to 30 September 2020 to identify the relevant studies. They finally analyzed 62 studies consisting of more than 250,157 participants and 22,608 cases. Smoking, alcohol, body mass index, physical activity, sleep time, medication, and diet comprised the seven lifestyle factors that were investigated. For smoking, alcohol consumption, body fatness, less sleep time, and proton pump inhibitors use, statistically significant elevated BE risks were found. Decreased BE risks were observed for aspirin and the consumption of vitamin C, folate, and fiber. Findings of this large meta-analysis demonstrated that reduction in the risks of BE and, consequently, esophageal adenocarcinoma, could be brought about by lifestyle modifications.