Pollock BD, et al. - Researchers conducted this prospective study that followed 1,269 Bogalusa Heart participants to analyze population-level cardiovascular risk trajectories over the life course and their influence on mid-life atherosclerotic and metabolic outcomes. Each participant had ≥ 4 study visits from childhood in 1973 through adulthood in 2016. The five distinct trajectory groups of life course cardiovascular risk—which were estimated between the mean ages of 9.6 to48.3 years—included High-Low, High-High, Mid-Low, Low-Low, and Low-High. According to findings, life course cardiovascular risk trajectory groups significantly determined adult metabolic and vascular outcomes. Lower risks of diabetes (20% vs 28%) and lower BMIs (32.4 kg/m² vs 34.6 kg/m²) were observed among those in the High-Low group vs those who remained at high risk (High-High) throughout life. However, better carotid intima-media thickness (0.89 mm vs 1.05 mm) and pulse wave velocity (7.8 m/s vs 8.2 m/s) were observed in the High-Low group vs the High-High group. For all outcomes, those in the Low-Low group fared best. Over the life course, a considerable movement was seen between low- and high-relative cardiovascular risk strata.