Wolf J, et al. - A single-center, observational cohort study of patients with newly diagnosed acute lymphoblastic leukemia (ALL) to assess the efficacy of levofloxacin prophylaxis during induction therapy for pediatric acute lymphoblastic leukemia. In this study, prophylaxis prevented febrile neutropenia and systemic infection. Levofloxacin prophylaxis resulted in minimization of the use of treatment antibiotics and a drastic reduction in C. difficile infection. Despite requiring long-term antibiotic-resistance monitoring, data support using targeted prophylaxis with levofloxacin in children undergoing induction chemotherapy for ALL.