Lazarinis N, et al. - This study was designed to test the hypothesis that current CysLT₁ receptor antagonists may provide incomplete inhibition of CysLT responses. For this purpose, researchers determined the impact of the CysLT₁ antagonist montelukast on responses induced by inhalation of leukotriene E₄ (LTE₄) in asthmatic subjects. They found that via the CysLT₁ receptor, leukotriene E₄ induced airflow obstruction and mast cell activation.