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Leucocyte telomere shortening is associated with nonalcoholic fatty liver disease-related advanced fibrosis

Liver International Jun 24, 2018

Kim D, et al. - Cross-sectional data from the National Health and Nutrition Examination Survey 1999-2002 was utilized in order to determine the impact of telomere length on nonalcoholic fatty liver disease and advanced fibrosis in a large nationally representative sample of American adults. Researchers determined the presence of advanced fibrosis by the nonalcoholic fatty liver disease fibrosis score, aspartate aminotransferase to platelet ratio index and FIB-4 score. The findings demonstrated that leucocyte telomere shortening was correlated with increased risk of advanced fibrosis in the setting of suspected nonalcoholic fatty liver disease independent of other known risk factors.
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