Chong CD, et al. - This study was carried out to investigate differences in cortical thickness in patients with persistent post-traumatic headache (PPTH) relative to healthy controls and to explore whether cortical morphology relates to headache burden (headache frequency, years with post-traumatic headache, PTH) in patients with PPTH. As per findings, in bilateral frontal regions and right hemisphere parietal regions patients with PPTH had less cortical thickness compared with healthy controls. More frequent headaches in patients with PPTH were correlated with less thickness in the left and right superior frontal regions. This suggests that brain morphology changes in the superior frontal regions in patients with PPTH are modified by headache frequency.