Abd-Elmaged WM, et al. - Experts gauged the possible role of interleukin (IL)-17 and 25 hydroxycholecalciferol (25(OH)D3) in the pathogenesis and progression of inflammatory acne. They performed ELISA assays of serum and tissue levels of IL-17 and 25(OH)D3, as well as immunohistochemical and Western blotting demonstration of the expression patterns of lesional IL-17 vs control group. A possible role in active acne vulgaris may be demonstrated by the deficiency of vitamin D3 accompanied with higher IL-17 in an inverse pattern. In active acne lesions, they noted higher IL-17 expression levels than its level in healthy skin of the controls.