D’Elia L, et al. – Given that leptin has been linked to an adverse cardiometabolic risk profile, researchers assessed the role of leptin on the incidence of insulin resistance in an 8-year follow-up sample of adult non-diabetic me without insulin resistance (n=527) in this prospective study. They found that baseline leptin was significantly and positively related to HOMA index, body mass index, waist circumference, and blood pressure levels. Findings showed that circulating leptins levels were predictive of a reduced insulin sensitivity over time, independently of main potential confounders, in non-diabetic men without insulin resistance at baseline. Additionally, leptin levels were associated with the development of IR in normal-weight individuals.