Mele D, et al. – The analysts applied parametric two–dimensional speckle–tracking echocardiography with polar plots of the amplitude and timing of left ventricular (LV) longitudinal strain to guide implantation of the LV lead, with the aim of increasing cardiac resynchronization therapy (CRT) response. The obtained data indicates that echocardiography–guided LV lead implantation on the basis of parametric polar plots of LV longitudinal myocardial strain increases both the number of responders and the magnitude of echocardiographic response to CRT. Size of transmural scar tissue negatively affects CRT response, even when LV lead position is optimized in ischemic patients.