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“Acute kidney dysfunction with no rejection” is associated with poor renal outcomes at 2 years post kidney transplantation

BMC Nephrology Jul 14, 2019

Paquot F, et al. - Given that “acute kidney dysfunction with no rejection” (ADNR) corresponds to acute kidney injury without histological proof of acute rejection (AR) in kidney transplant recipients (KTR), researchers focused on the prognosis of ADNR. ADNR (n = 93) and biopsy-proven AR (n = 22) were the categories defined for KTR with for-cause kidney biopsy within the first 12 months after kidney transplantation (KTx). This study also included 135 controls (C) comprising KTR with no ADNR or AR within the first 24 months post-KTx. In C, a significantly higher eGFR was reported at 12 months, compared with ADNR as well as AR. Findings revealed the association of ADNR with poor outcomes within 2 years post-KTx.
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