Zhang XX, Wei M, Shang LX, et al. - In patients with non-valvular atrial fibrillation (NVAF) in Xinjiang, researchers sought to assess the connections between the low−/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and other clinical indicators and ischaemic stroke (IS). Based on the incidence of the first acute IS, NVAF patients who were admitted to 10 medical centers across Xinjiang were divided into stroke (798 patients) and control (2,671 patients) groups. The stroke group had an average age of 71.64 ± 9.96 years and involved 305 females (38.22%) and the control group had a mean age of 67.30 ± 12.01 years and involved 825 females (30.89%). Independent risk factors for IS were LDL-C/HDL-C > 1.22, smoking, BMI ≥ 24 kg/m² and CHA₂DS₂-VASc score in NVAF patients. The main risk factor was LDL-C/HDL-C.