Seremidi K, et al. - In this systematic review and meta-analysis, researchers assessed the prevalence of dental defects following chemo and radiation therapy and linked the findings with particular features of each treatment modality. For this investigation, 16 nonrandomized studies were included, with a total of 1,300 subjects whose mean age at diagnosis was 4.5 years. Compared to crown defects, root defects were more common, with impaired root growth as the most common root defect. The most common crown defect was microdontia. A higher prevalence of dental defects was linked statistically to age, radiation dose and field. Overall, defects correlated to a combination of chemotherapy and radiotherapy, as used in contemporary antineoplastic modalities.