Weinreb RN, et al. - This study was designed to compare the diurnal intraocular pressure (IOP)-lowering effect of latanoprostene bunod (LBN) 0.024% with timolol maleate 0.5% in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT). LBN 0.024% once daily provided greater IOP-lowering compared with timolol 0.5% twice daily and maintained lowered IOP through 12 months in this pooled analysis of subjects with OAG and OHT. LBN, relative to prostaglandin analogs, had comparable safety profile.