Eggenschwiler CDC, et al. - In this retrospective systematic single-center analysis, researchers tested the safety and effectiveness of quality-switched ruby, quality-switched Nd:YAG and picosecond lasers in the treatment of accidental hyperpigmentation in a larger patient cohort. This investigation was performed on 70 individuals, which presented with accidental hyperpigmentation at the Dermatology Department of the University Hospital of Zurich between 2008 and 2017. Included were patients with accidental tattoos due to road injuries, explosives or other traumas and iatrogenic measures. In treating accidental hyperpigmentation, the authors show the effectiveness and safety of quality-switched and picosecond lasers. This is advised to improve effectiveness by using a mixture of different wavelengths and pulse lengths on the same lesion, and gradually increasing the fluence during laser treatment. Compared with tattoos located on the extremities and those caused by explosions, piercings or iatrogenic measures or consisting of metal pigment particles, they noticed a tendency towards faster elimination of facial accidental tattoos and/or originating from road injuries.