Nijenhuis-Rosien L, Kleefstra N, van Dijk PR, et al. - In this randomized, quadruple-blind, sham-controlled trial, researchers assessed the effectiveness and safety of the treatment of onychomycosis with local laser therapy. For this analysis, patients with diabetes mellitus microbiological confirmation at risk of developing diabetic foot ulcers and a clinical suspicion on onychomycosis were randomized to either four sessions neodymium-doped yttrium aluminium garnet (Nd-YAG) 1064 nm laser or sham therapy. Data reported that the most detected pathogen was Trichophyton rubrum. No difference was discovered in the primary outcome between laser and sham treatment. The authors concluded that treatment with Nd-YAG 1064 nm laser is secure, with the exception of a subungual haematoma in the fifth toenail that occurs 2 weeks after laser therapy. There is currently no proof of any impact of onychomycosis laser therapy in patients with diabetes at enhanced danger of foot ulcers, at least not within 1 year of therapy.