Cesareo R, Manfrini S, Pasqualini V, et al. - In this single-center, 12-month, randomized, superiority, open-label, parallel-group trial, researchers sought to compare the effectiveness and safety of both treatments at 12-month follow-up in patients with solid or predominantly solid benign non-functioning thyroid nodule (BNTN). For this analysis, 60 patients with a solitary BNTN or dominant nodule characterized by pressure symptoms/cosmetic problems were randomly assigned (1:1 ratio) to undergo either a single session of radiofrequency ablation (RFA) or laser ablation (LA). At 12 months, in the RFA and LA groups, VRR was 70.9 ± 16.9% and 60.0 ± 19.0%, respectively. No significant between-group difference was noted in the technical success rate at 12 months posttreatment. At 12 months, the RFA achieved a significantly larger nodule volume reduction, but the technical success rate in the RFA and LA groups was comparable.