Youngerman BE, et al. - The intention of the authors was to investigate the safety and efficacy of selective laser amygdalohippocampotomy (SLAH) using magnetic resonance–guided laser interstitial thermal therapy (MRgLITT) is emerging for the treatment of drug-resistant mesial temporal lobe epilepsy (MTLE). Similar rates of seizure freedom were illustrated following SLAH in patients with mesial temporal sclerosis (MTS) and stereoelectroencephalography (SEEG)-confirmed, non-MTS MTLE. These rates appeared to be slightly lower than typically observed with surgical resection (60%-80%). Nonetheless, SLAH was a less invasive approach when compared to open surgery. It presented with shorter hospital stays and recovery, with rare severe procedural complications. For patients with both MTS and SEEG confirmed, non-MTS MTLE, SLAH could serve as a reasonable first-line surgical choice.