Donos C, et al. - The connections between ablation volumes and surgical or cognitive outcomes in 43 consecutive patients undergoing laser interstitial thermal therapy (LITT) for mesial temporal lobe (MTL) epilepsy was evaluated in this analysis. Researchers utilized FreeSurfer software to derive cortical and subcortical segmentation of the brain (especially subregions of the MTL) using preoperative magnetic resonance imaging (MRI). In carefully selected patients with and without mesial temporal sclerosis, seizure-free outcomes following LITT could be comparable and these outcomes were comparable with outcomes following microsurgical resection. Failures could result from non-mesial components of the epileptogenic network that were not affected by LITT. Findings revealed that cognitive declines following MTL-LITT were modest, and principally affect memory processes.