Mayr U, et al. - In this study performed on critically ill patients with decompensated cirrhosis, researchers assessed the influence of large-volume paracentesis (LVP) on plasma disappearance rate of indo-cyanine green (ICG) [ICG-PDR] as well as on intraabdominal pressure (IAP), abdominal perfusion pressure (APP), hepatic blood flow, hemodynamic and respiratory function. They detected that ICG-PDR was dramatically impaired among critically ill patients with decompensated cirrhosis and elevated IAP. In parallel with a decreased IAP and an increased APP, paracentesis-induced improvement in ICG-PDR was observed, while no change was observed in conventional parameters of liver function. This impact on ICG-PDR was primarily associated with a relief of intraabdominal hypertension and changes in hepatosplanchnic blood flow.